MersV1, Main, Exploration, bibRecord, 003F67

Handling of retroviral antigens by human antigen-presenting cells

Identifieur interne : 003F67 ( Main/Exploration ); précédent : 003F66; suivant : 003F68

Handling of retroviral antigens by human antigen-presenting cells

Auteurs : D. Fenoglio [Italie] ; G. Li Pira [Italie] ; D. Saverino [Italie] ; A. Ferraris [Italie] ; F. Lancia [Italie] ; A. Megiovanni [Italie] ; L. Oppezzi [Italie] ; G. Piatti [Italie] ; F. Buffa [Italie] ; M. T. Valle [Italie] ; A. Kunkl [Italie] ; F. Manca [Italie]

Source :

Research in Virology [ 0923-2516 ] ; 1996.

RBID : ISTEX:D672F3ED19889EBB6C8DD321818E5B75A1D86C4F

English descriptors

KwdEn :
- APC, HIV, HTLV-1, Human T clones, Immunogenicity, Intrastructural help, Molecular context, Retroviral antigens, T lymphocyte, gp120 p66.
Teeft :
- Antibody production, Antigen, Antigen complexed, Antigen presentation, Antigen uptake, Apc, Clonal expansion, Clone, Dendritic ceils, Different populations, Effector mechanisms, Envelope glycoprotein, Favours contact, Fenoglio, Helper cells, Helper clones, High efficiency, Human clones, Immune, Immune complexes, Immune defic, Immune response, Immunol, Kunkl, Langerhans cells, Lymphocyte, Manca, Molecular context, Monoclonal antibodies, Mononuclear cells, Neutralizing antibodies, Peptide, Pira, Present antigen, Relevant antigens, Retroviral, Retroviral antigens, Retroviral infections, Secondary responses, Surface immunoglobulins, Synthetic peptides, Viral particles.

Abstract

Summary: Antigen-specific T helper cells play an important role in retroviral infections. Indeed, they provide help for B-cell activation and antibody production and for clonal expansion of cytolytic lymphocytes. Therefore, we used retrovirus-specific human T helper clones in order to define modes of antigen presentation, antigen-presenting cells and the molecular context of Th epitopes that could be exploited in the design of immunogens aimed at optimizing the Th cell response. In particular, we describe several mechanisms of receptor-mediated antigen uptake that enhance the stimulation of human T-cell clones specific for HIV and HTLV-1 antigens; we report on the differential recognition of Th epitopes depending on the molecular-viral context; we show that dendritic cells are the most efficient presenting cells and are essential for the induction of in vitro primary Th cell responses; and finally, we propose that Th cells specific for internal, conserved antigens of HIV such as reverse transcriptase, may be candidates for intrastructural help resulting in induction of envelope specific antibodies.

Url:

https://api.istex.fr/ark:/67375/6H6-9THT98CL-9/fulltext.pdf

DOI: 10.1016/0923-2516(96)80222-6

Affiliations:

Italie

Links toward previous steps (curation, corpus...)

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to stream Main, to step Merge: 004022
to stream Main, to step Curation: 003F67

Le document en format XML

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<author><name sortKey="Saverino, D" sort="Saverino, D" uniqKey="Saverino D" first="D." last="Saverino">D. Saverino</name>
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<author><name sortKey="Ferraris, A" sort="Ferraris, A" uniqKey="Ferraris A" first="A." last="Ferraris">A. Ferraris</name>
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<author><name sortKey="Megiovanni, A" sort="Megiovanni, A" uniqKey="Megiovanni A" first="A." last="Megiovanni">A. Megiovanni</name>
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<author><name sortKey="Valle, M T" sort="Valle, M T" uniqKey="Valle M" first="M. T." last="Valle">M. T. Valle</name>
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<term>Immunogenicity</term>
<term>Intrastructural help</term>
<term>Molecular context</term>
<term>Retroviral antigens</term>
<term>T lymphocyte</term>
<term>gp120 p66</term>
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<term>Antigen complexed</term>
<term>Antigen presentation</term>
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<term>Apc</term>
<term>Clonal expansion</term>
<term>Clone</term>
<term>Dendritic ceils</term>
<term>Different populations</term>
<term>Effector mechanisms</term>
<term>Envelope glycoprotein</term>
<term>Favours contact</term>
<term>Fenoglio</term>
<term>Helper cells</term>
<term>Helper clones</term>
<term>High efficiency</term>
<term>Human clones</term>
<term>Immune</term>
<term>Immune complexes</term>
<term>Immune defic</term>
<term>Immune response</term>
<term>Immunol</term>
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<term>Manca</term>
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<term>Monoclonal antibodies</term>
<term>Mononuclear cells</term>
<term>Neutralizing antibodies</term>
<term>Peptide</term>
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<term>Present antigen</term>
<term>Relevant antigens</term>
<term>Retroviral</term>
<term>Retroviral antigens</term>
<term>Retroviral infections</term>
<term>Secondary responses</term>
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<front><div type="abstract" xml:lang="en">Summary: Antigen-specific T helper cells play an important role in retroviral infections. Indeed, they provide help for B-cell activation and antibody production and for clonal expansion of cytolytic lymphocytes. Therefore, we used retrovirus-specific human T helper clones in order to define modes of antigen presentation, antigen-presenting cells and the molecular context of Th epitopes that could be exploited in the design of immunogens aimed at optimizing the Th cell response. In particular, we describe several mechanisms of receptor-mediated antigen uptake that enhance the stimulation of human T-cell clones specific for HIV and HTLV-1 antigens; we report on the differential recognition of Th epitopes depending on the molecular-viral context; we show that dendritic cells are the most efficient presenting cells and are essential for the induction of in vitro primary Th cell responses; and finally, we propose that Th cells specific for internal, conserved antigens of HIV such as reverse transcriptase, may be candidates for intrastructural help resulting in induction of envelope specific antibodies.</div>
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Handling of retroviral antigens by human antigen-presenting cells

Handling of retroviral antigens by human antigen-presenting cells

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri